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Levitra 10mg (Vardenafil HCL) , (als Hydrochloridetrihydraat) by Bayer

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Product Description

Levitra (Vardenafil HCL)

Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction that is sold under the trade names Levitra (Bayer AGGSK, and SP) and Staxyn.

 

Contents

  • 1 History
  • 2 Clinical use
    • 2.1 Adverse drug reactions
    • 2.2 Drug interactions
    • 2.3 Dose forms
  • 3 Notes
  • 4 External links
  •  

    History

    Vardenafil was co-marketed by Bayer Pharmaceuticals, GlaxoSmithKline, and Schering-Plough under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been returned to Bayer in many markets outside the U.S. In Italy, Bayer sells vardenafil as Levitra and GSK sells it as Vivanza. Thus, because of European Union trade rules, parallel imports might result inVivanza sold next to Levitra in the EU.

    An orally disintegrating form, marketed as Staxyn, has been gaining approvals in countries such as the United States and Canada.

     

    Clinical use

    Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafilcitrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.

    Beyond its indications for erectile dysfunction, vardenafil may be effective in the treatment of premature ejaculation, where it may significantly increase the time from vaginal penetration to ejaculation. 

    Adverse drug reactions

    The common, adverse drug reactions (side-effects) are the same as with other PDE5 inhibitors. The frequent vardenafil-specific side-effect is nausea; the infrequent side-effects are: abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial oedema,hypotension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, and priapism. (Rossi, 2004)

    One possibly serious, but rare, side-effect with vardenafil is heart attack. Also, in rare cases, vardenafil use may cause priapism, a very painful emergency condition that can cause impotence if left untreated. 

    On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden hearing loss) would be added to the drug labels of Vardenafil, and other PDE5 inhibitors.

    Drug interactions

    Vardenafil, as with all PDE5 inhibitors, should not be used by men taking nitrate medications, because combining them with vardenafil might provoke potentially life-threateninghypotension (low blood pressure).

    Further, Vardenafil causing lengthening of the QT interval. Therefore it should not be taken by men taking other medications at affect the QT interval (such as amiodarone).

    Dose forms

    It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Vardenafil should be taken 1 to 2 hours prior to sexual activity, with a maximum dose frequency of once per day. In some territories, such as the UK, only certain doses may be available.

    Vardenafil is also available under the name Staxyn as a tablet which dissolves on the tongue rather than being swallowed in the form of a pill.

     

    Notes

    1. ^ http://www.pharmpro.com/News/Feeds/2010/06/pharmaceutical-companies-bayer-new-erectile-dysfunction-treatment-staxyn-approve/
    2. ^ http://www.newswire.ca/en/story/832217/staxyn-new-innovation-in-erectile-dysfunction-helps-younger-men-rise-to-the-occasion
    3. ^ A Aversa et al.. "Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation". Retrieved 2010-12-14.
    4. ^ Schools of Pharmacy (Glen L. Stimmel, Pharm.D., and Mary A. Gutierrez, Pharm.D.) and Medicine (Glen L. Stimmel, Pharm.D.), University of Southern California, Los Angeles, California.. "Counseling Patients About Sexual Issues: Drug-Induced Priapism". Medscape. Retrieved 2010-12-06.
    5. ^ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra". Food and Drug Administration. 2007-10-18. Retrieved 2009-08-06.

     

    External links

    • Official Levitra website
    • PubChem Information

     

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