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Analgesic, non-narcotic


An analgesic (also known as a painkiller) is any member of the group of drugs used to relieve pain (achieve analgesia). The word analgesicderives from Greek an- ("without") and algos ("pain").

Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (para-acetylaminophenol, also known in the US as acetaminophen), the non-steroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, and opioid drugs such asmorphine and opium. They are distinct from anesthetics, which reversibly eliminate sensation.

In choosing analgesics, the severity and response to other medication determines the choice of agent; the WHO pain ladder, originally developed in cancer-related pain, is widely applied to find suitable drugs in a stepwise manner.The analgesic choice is also determined by the type of pain: for neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants.


A third of Americans over 65 use nonsteroidal anti-inflammatory drugs (NSAIDs) every day, according to the American Pain Foundation. For the chronic pain patient, it's critical to understand the most basic drugs in your war on pain.

Most painkillers (or analgesics, from the Greek term for the absence of pain) work on the central nervous system—the brain and the spinal cord—and the peripheral nervous system, which connects the rest of the body to them, sending signals back and forth. 

Painkillers are generally broken down into three categories: opioid(narcotic) analgesics, non-narcotic analgesics (which include NSAIDs), and adjuvant therapies such as anticonvulsants, muscle relaxants, andantidepressants. We'll deal with NSAIDs here.

How NSAIDs work
The granddaddy of NSAIDs is aspirin (acetylsalicylic acid), made from a compound found in willow bark and introduced into modern medicine in 1899. Ibuprofen, a non-aspirin analgesic, was introduced in 1974 and is best known as Advil or Motrin. Naproxen was first marketed in 1976, and is best known as Aleve.

More about pain medication
  • Using Over-the-Counter Drugs Safely
  • A Guide to Nonsteroidal Anti-Inflammatory Drugs
  • Stay Alert for NSAID Side Effects

The COX-2 inhibitors
In the 1990s drugs were developed to solve the NSAIDs stomach problem. Known as COX-2 inhibitors, they primarily disable the COX-2 enzyme, leaving the COX-1 to do its job protecting the stomach. Vioxx, Celebrex, and Bextra were widely marketed, and became hugely popular prescription-only painkillers. However, in 2004 studies showed that Vioxx can increase the risk of heart attack and stroke, and its maker, Merck, yanked it from the market. More than a dozen cases went to court, and although Merck won many of them, some cases resulted in huge damages against the company. In November 2007 Merck agreed to a massive payout of $4.85 billion to settle thousands of additional cases. In 2005 Bextra was also removed. Celebrex remains on the market.

The new concerns prompted the FDA in 2005 to require new warnings on all NSAIDs (except aspirin), stating the risk of stomach, heart, or skin problems. Ulcers and gastrointestinal bleeding linked to the use of NSAIDs are responsible for an estimated 15,000 to 20,000 deaths in the U.S. each year, and more than 100,000 hospitalizations, according to the American College of Gastroenterology. In February 2007 the American Heart Association advised physicians that, except for aspirin, NSAIDs and especially COX-2 inhibitors should be used only as a last line of treatment for people with heart disease or heart disease risk factors. 

All NSAIDs present an additional risk of kidney damage when used at high doses for a prolonged period of time.

The special case of acetaminophen
Acetaminophen, best known as Tylenol, isn't an NSAID. Its exact painkilling mechanism is not fully understood, and it doesn't reduce inflammation. Nor does acetaminophen have many side effects—except one whopper: It can damage the liver, sometimes fatally, if taken in large doses or by someone with liver disease (sometimes caused by long-term, regular use of alcohol).

When you calculate your daily acetaminophen or NSAID intake, watch for hidden sources. Pain patients can overdose unwittingly if they lay a dose of Tylenol, for example, over a med which combines another drug with acetaminophen, as do some opioid drugs, such as Vicodin and Percocet. Some over-the-counter remedies also bundle in acetaminophen or NSAIDs, such as Theraflu, Alka-Seltzer, and NyQuil Cold & Flu.

Taken in correct doses, however, the non-narcotic pain drugs are usually safe and can work temporary wonders.

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